Elastin Products Company, Inc.
P.O. Box 568
Owensville, Missouri, USA 65066
Phone: 573-437-2193
Fax: 573-437-4632
email: epc@elastin.com

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Description

GM6001, ilomastat, Galardin�

Molecular Formula: C₂₀H₂₈N₄O₄
FW 388.47

Prepared by the method of Grobelny et al (1).

Inhibits a wide varietyof matrix metalloproteases with Ki�s in the nanomolar range (1, 2).

Active in a number of animal models of diseases where matrixmetalloproteases are thought to be involved (2, 3, 4, 5, 6).

Purity is greater than 95 % as determined by HPLC.
Ki 1 nM or less against humanskin fibroblast collagenase, human 72 kd gelatinase, human 92 kdgelatinase and human neutrophil collagenase, Ki 27 nM against humanstromelysin (2).

References:

(1.)Grobelny, D., Poncz, L. and Galardy, R. E. 1992. Inhibition of Human Skin Fibroblast Collagenase, Thermolysin, and PseudomonasAeruginosa Elastase by Peptide Hydroxamic Acids. Biochemistry 31:7152-7154.
(2.) Galardy, R.E., M. E.Casabonne, C. Giese, J.H. Gilbert, F. Lapierre,H. Lopez, M.E. Schaefer, R. Stack, M. Sullivan, B. Summers, R. T. D.Tyrrell, J. Wee, S.D. Allen J.J. Castellot, J.P. Barletta, G.S. Schultz,L.A. Fernandez, S. Fisher, T.-.Y Cui, H.G. Foell-mer, D. Grobelny, andW.M. Holle-ran 1994. Low Molecular Weight Inhibitors in CornealUlceration, Ann NY Acad. Sci. 732: 315-323.
(3.) Bendeck, M.P., Zempo. N., Clowes, A.W., Galardy, R.E., and Reidy,M.A.1994. Smooth Muscle Cell Migration and Matrix MetalloproteaseExpression After Arterial Injury in the Rat. Circ. Res. 75: 539-545.
(4.) Gijbels, K., Galardy, R.E., and Steinman, L. 1994. Reversal ofExperimental Autoimmune Encephalomyelitis with a Hydroxamate Inhibitorof Matrix Metalloproteases. J. Clin. Invest. 94: 2177-2182.
(5.) Wang, P., Ba, Z.F., Galardy, R.E., and Chaudry. I.H. 1996.Administration of a Matrix Metalloproteinase Inhibitor after HemorrhageImproves Cardiovascular and Hepatocellular Function. Shock 6: 377-382.
(6.) Solorzano, C.C., Ksontini, R., Pruitt, J.H., Auffenberg, T.,Tannahill C., Galardy, R.E., Schultz, G.P., MacKay, S.L.D., Copeland,E.M., and Moldawer, L.L. 1997. A Matrix Metalloproteinase InhibitorPrevents Processing of Tumor Necrosis Factor a (TNFa) and Abrogates Endotoxin-Induced Lethality. Schock 7:427-431

Contact Information

Elastin Products Company, Inc.
P.O. Box 568
Owensville, Missouri, USA 65066
Phone: 573-437-2193
Fax: 573-437-4632
email: epc@elastin.com

As an Elastin Products Company, Inc. client, now you can enjoy the simple, fast and secure method of ordering your products at anytime during the day or night at your own convenience utilizing the Internet. You can place orders using our Web Site, Secure Fax, Phone, e-mail: epc@elastin.com or US Mail.

Manufacture Policy

All items listed herein are manufactured by processes designed by Elastin Products Company, Inc., by cited literature methods with modifications or as custom preparations for EPC by qualified scientists. Each item is tested for activity and/or purity before released to a client.

Warranty

Elastin Products Company, Inc. (EPC) warrants that its products are merchantable quality and warrants the accuracy of its description of such products. EPC warrants that the products described herein has performed as disclosed by EPC. Purchaser must determine suitability of the product for any unusual or particular purpose. THIS WARRANTY IS EXCLUSIVE AND EPC MAKES NO OTHER WARRANTY, EXPRESSED OR IMPLIED, THAT THE PRODUCT DESCRIBED HEREIN IS MERCHANTABLE OR FIT FOR ANY PARTICULAR PURPOSE. Whenever any items(s) leaves our premises, such items(s) are absolutely out of our control. EPC therefore makes no warranty as to fitness for any particular purpose or to protection against patent, copyright and trade mark infrigement. In any and all situations it is the total responsibility of the buyer and/or user to determine any and all possible patent, copyright and trade.